Description

2-Bromo-4,5-Difluorobenzaldehyde is a versatile and high-purity fluorinated aromatic aldehyde building block, essential for advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the difluorobenzene moiety can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated mesogens and electron-transport materials in display technologies and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl and conjugated systems.
• Functional Polymer Monomer: Incorporated into polymer backbones to impart specific properties such as chemical resistance, thermal stability, or unique optical characteristics.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Bromo-4,5-Difluorobenzaldehyde
CAS No.	476620-54-9
Molecular Formula	C7H3BrF2O
Molecular Weight	221.00 g/mol
Synonyms	4,5-Difluoro-2-bromobenzaldehyde; Benzaldehyde, 2-bromo-4,5-difluoro-; 2-Bromo-4,5-difluorobenzenecarboxaldehyde; 4,5-Difluoro-2-bromobenzenecarbaldehyde; (2-Bromo-4,5-difluorophenyl)methanal
EINECS	Contact for details

Quality Control

Our 2-Bromo-4,5-Difluorobenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents, strong bases, and reducing agents. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.