Description

1,1-Difluoro-4-(Iodomethyl)Cyclohexane is a versatile fluorinated and iodinated cyclohexane derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both difluoro and iodomethyl functional groups, makes it a valuable precursor for introducing fluorinated motifs and enabling further functionalization via cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, where the fluorine atoms can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated components used in display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: The iodomethyl group acts as a reactive handle for Suzuki, Negishi, and other palladium-catalyzed coupling reactions to construct complex molecular architectures.
• Fluorine Chemistry Research: An important reagent in academic and industrial R&D for studying the effects of fluorine substitution on physical and chemical properties.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering their surface properties, solubility, and thermal stability.

Basic Information

Product Name	1,1-Difluoro-4-(Iodomethyl)Cyclohexane
CAS No.	476415-02-8
Molecular Formula	C7H11F2I
Molecular Weight	256.06 g/mol
Synonyms	4-(Iodomethyl)-1,1-difluorocyclohexane; 1,1-Difluoro-4-iodomethylcyclohexane; Cyclohexane, 1,1-difluoro-4-(iodomethyl)-; (4-(Iodomethyl)cyclohexylidene)difluoride
EINECS	Contact for details

Quality Control

Every batch of 1,1-Difluoro-4-(Iodomethyl)Cyclohexane is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards and customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is available upon request and accompanies each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C/59-77°F). Due to its light-sensitive nature and propensity for oxidation, it is recommended to store this material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Specific Impurity A	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.