Description

n-Tips Indole-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critically important for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex indole-based drug candidates, including kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLEDs and conductive polymers.
• Academic & R&D: Essential reagent in university and corporate laboratories for methodological development and exploring new chemical spaces.
• Ligand Synthesis: Used to prepare specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	n-Tips Indole-3-Boronic Acid Pinacol Ester
CAS No.	476004-82-7
Molecular Formula	C₂₃H₃₀BNO₂
Molecular Weight	363.30 g/mol
Synonyms	1H-Indole-3-boronic acid, 1-(1,1-dimethylethyl)-2-methyl-1-propan-2-yl ester; 1-TIPS-indole-3-boronic acid pinacol ester; 1-[(Triisopropylsilyl)methyl]indole-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[(triisopropylsilyl)methyl]-1H-indole; Indole-3-boronic acid pinacol ester, N-TIPS protected; N-TIPS-3-Indoleboronic acid pinacol ester; 1-TIPS-1H-indole-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-Tips Indole-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.