Description

5-Methylthiophene-2-Boronic Acid Pinacol Ester, 95% is a high-purity organoboron reagent, specifically a protected boronic acid derivative, essential for modern synthetic chemistry. This compound is a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecules for advanced material and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel thiophene-based compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between the thiophene ring and aryl or vinyl halides, fundamental in medicinal chemistry.
• Pharmaceutical Intermediate Synthesis: Serves as a versatile precursor in the development of active pharmaceutical ingredients (APIs), particularly those containing functionalized thiophene moieties.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that leverage the unique properties of the thiophene scaffold.
• Organic Electronic Materials: A building block for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and solar cells.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for transition metal catalysis and organocatalysts.
• Chemical Biology & Probe Development: Useful for creating molecular probes and bioconjugates for studying biological systems.

Basic Information

Product Name	5-Methylthiophene-2-Boronic Acid Pinacol Ester, 95%
CAS No.	476004-80-5
Molecular Formula	C11H19BO2S
Molecular Weight	226.14 g/mol
Synonyms	5-Methyl-2-thienylboronic acid pinacol ester; 2-(5-Methylthiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Methylthiophene-2-boronic acid neopentyl glycol ester (common name); 5-Methyl-2-thienyl-Bpin; 2-(5-Methyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B-(5-Methyl-2-thienyl)boronic acid pinacol ester; 476004-80-5
EINECS	Contact for details

Quality Control

Our 5-Methylthiophene-2-Boronic Acid Pinacol Ester is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including NMR (1H, 13C, 11B), HPLC, and GC to confirm identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (argon or nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.