Description

2-(Trifluoromethyl)Benzylboronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and the synthesis of novel fluorinated compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl and heterobiaryl structures, which are common motifs in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of new drug candidates, particularly those incorporating the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers where specific fluorinated aromatic units are required.
• Chemical Biology & Medicinal Chemistry: Facilitates the synthesis of probe molecules and labeled compounds for biological target identification and validation.

Basic Information

Product Name	2-(Trifluoromethyl)Benzylboronic Acid Pinacol Ester
CAS No.	475250-54-5
Molecular Formula	C14H18BF3O2
Molecular Weight	286.10 g/mol
Synonyms	2-(Trifluoromethyl)benzylboronic acid pinacol ester; (2-(Trifluoromethyl)benzyl)boronic acid pinacol ester; 2-(Trifluoromethyl)benzylboronic acid, pinacol ester; 2-(Trifluoromethyl)benzylboronate pinacol ester; 4,4,5,5-Tetramethyl-2-[2-(trifluoromethyl)benzyl]-1,3,2-dioxaborolane; α-(Trifluoromethyl)benzylboronic acid pinacol ester; Pinacol [2-(trifluoromethyl)benzyl]boronate
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Benzylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.