Description

4-(Trifluoromethyl)Benzylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is crucial for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds in advanced chemical synthesis. It is an essential building block for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, facilitating the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing the trifluoromethylbenzyl moiety, which can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the introduction of specific aromatic systems is required.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers via palladium-catalyzed coupling reactions.
• Chemical Biology & Medicinal Chemistry: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes and drug candidates in discovery pipelines.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura cross-coupling with various organic halides to form biaryl and other extended conjugated systems.
• Process Chemistry & Scale-Up: Suitable for use in kilogram-scale laboratory and pilot plant syntheses due to its stability as a pinacol ester.

Basic Information

Product Name	4-(Trifluoromethyl)Benzylboronic Acid Pinacol Ester
CAS No.	475250-46-5
Molecular Formula	C14H18BF3O2
Molecular Weight	286.10 g/mol
Synonyms	[4-(Trifluoromethyl)phenyl]methylboronic acid pinacol ester; (4-(Trifluoromethyl)benzyl)boronic acid pinacol ester; Pinacol [4-(trifluoromethyl)benzyl]boronate; 4-(Trifluoromethyl)benzylboronic acid, pinacol ester; B-[4-(Trifluoromethyl)benzyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-Trifluoromethylbenzyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[4-(trifluoromethyl)benzyl]-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Benzylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.