Description

4-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl)Benzonitrile is a high-value, synthetically versatile organoboron building block, specifically a pinacol boronate ester derivative. Its core value proposition lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and advanced materials synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl or substituted benzonitrile motifs.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides through palladium-catalyzed cross-coupling methodologies.
• Material Science & Organic Electronics: Serves as a building block for conjugated polymers, organic light-emitting diodes (OLEDs), and other functional materials requiring precise aryl-aryl linkages.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic pathways and creating compound libraries for screening.
• Ligand & Catalyst Preparation: Employed in the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	4-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl)Benzonitrile
CAS No.	475250-43-2
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	4-(Pinacolborylmethyl)benzonitrile; (4-Cyanobenzyl)boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ylmethyl)benzonitrile; 4-Cyanobenzylboronic acid pinacol ester; 4-(Boronatomethyl)benzonitrile pinacol ester; B-(4-Cyanobenzyl)boronic acid pinacol ester; 4-[(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]benzonitrile
EINECS	Contact for details

Quality Control

Our 4-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent specifications for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to prevent hydrolysis of the boronate ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.