Description

Carbamic Acid, (4-Formylphenyl)-, 9H-Fluoren-9-Ylmethyl Ester (CAS 475160-85-1) is a specialized, high-purity chemical building block of significant interest in advanced organic synthesis. This compound is valued for its dual functionality, incorporating both a protected amine (Fmoc) and an aldehyde group, which makes it a versatile intermediate for constructing complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical development companies engaged in peptide synthesis, combinatorial chemistry, and the creation of novel drug candidates and biochemical probes.

Application

• Peptide Synthesis Intermediate: Serves as a key building block for introducing aldehyde-functionalized amino acid derivatives into peptide chains using Fmoc solid-phase peptide synthesis (SPPS) strategies.
• Bioconjugation and Linker Chemistry: Utilized to create aldehyde-containing linkers for coupling biomolecules (proteins, antibodies) to surfaces, dyes, or other functional molecules via oxime or hydrazone ligation.
• Combinatorial Library Development: Employed in the generation of diverse chemical libraries for high-throughput screening in drug discovery programs.
• Protecting Group Strategy: The Fmoc group provides orthogonal amine protection, allowing for sequential, controlled deprotection in multi-step synthetic routes.
• Material Science Research: Used in the synthesis of functionalized polymers and dendrimers with precise chemical handles for further modification.
• Diagnostic Reagent Development: Acts as a precursor for synthesizing labeled compounds and probes used in immunoassays and other diagnostic applications.

Basic Information

Product Name	Carbamic Acid, (4-Formylphenyl)-, 9H-Fluoren-9-Ylmethyl Ester
CAS No.	475160-85-1
Molecular Formula	C23H17NO3
Molecular Weight	355.39 g/mol
Synonyms	4-Formylphenylcarbamic Acid 9-Fluorenylmethyl Ester; Fmoc-4-Aminobenzaldehyde; N-Fmoc-4-aminobenzaldehyde; N-(9-Fluorenylmethoxycarbonyl)-4-aminobenzaldehyde; 4-(Fmoc-amino)benzaldehyde; Fmoc-4-Abz-OH (aldehyde form); (4-Formylphenyl)carbamic Acid 9H-Fluoren-9-Ylmethyl Ester; 4-(9H-Fluoren-9-ylmethoxycarbonylamino)benzaldehyde
EINECS	Contact for details

Quality Control

Our Carbamic Acid, (4-Formylphenyl)-, 9H-Fluoren-9-Ylmethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.