Description

Methyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Trityl-1H-Pyrazole-3-Carboxylate is a high-value, multi-functional chemical building block designed for advanced synthetic applications. Its core value lies in the strategic combination of a protected pyrazole carboxylic ester and a pinacol boronate ester, enabling precise cross-coupling and functional group transformations. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety makes it an excellent partner for palladium-catalyzed cross-coupling to form carbon-carbon bonds, a fundamental reaction in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the pyrazole core's bioactivity.
• Material Science Research: Serves as a precursor for creating functional organic molecules and ligands used in catalysis and advanced materials.
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and labeled compounds due to its derivatizable ester and boronate functional groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized boron-containing intermediates.

Basic Information

Product Name	Methyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Trityl-1H-Pyrazole-3-Carboxylate
CAS No.	474711-42-7
Molecular Formula	C31H33BN2O4
Molecular Weight	508.42 g/mol
Synonyms	1-Trityl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carboxylic acid methyl ester; Methyl 1-trityl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-3-carboxylate; 1H-Pyrazole-3-carboxylic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triphenylmethyl)-, methyl ester; Methyl 4-(pinacolatoboryl)-1-trityl-1H-pyrazole-3-carboxylate; 4-Pinacolatoboryl-1-trityl-1H-pyrazole-3-carboxylic acid methyl ester; CAS 474711-42-7
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Trityl-1H-Pyrazole-3-Carboxylate undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, critical for sensitive synthetic applications. Our quality assurance protocols are designed to meet the stringent requirements of research and development as well as scale-up processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation, especially after opening the original container. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.