Description

Benzoic Acid, 2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical Suzuki-Miyaura cross-coupling building block, enabling the efficient construction of complex fluorinated aromatic systems. It is essential for researchers and process chemists in pharmaceutical development and agrochemical synthesis who require precise, reliable intermediates for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) containing fluorinated biphenyl or aryl motifs, leveraging the Suzuki-Miyaura cross-coupling reaction.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides where the fluorine atom and boronate group enhance biological activity and metabolic stability.
• Material Science Research: Used in the creation of advanced organic electronic materials, such as fluorinated polymers and small molecules for OLEDs or OFETs.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital intermediate for custom synthesis houses serving the life sciences industry, enabling rapid prototyping and scale-up of novel compounds.

Basic Information

Product Name	Benzoic Acid, 2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester
CAS No.	474710-54-8
Molecular Formula	C15H20BFO4
Molecular Weight	294.13 g/mol
Synonyms	Ethyl 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid Ethyl Ester; 5-Borono-2-fluorobenzoic Acid Ethyl Ester, Pinacol Ester; 2-Fluoro-5-(pinacolatoboron)benzoic Acid Ethyl Ester; (5-(Ethoxycarbonyl)-2-fluorophenyl)boronic Acid Pinacol Ester; 474710-54-8; AKOS005258155
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 2-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Ethyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency for critical R&D and scale-up applications. All products undergo rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) when not in use to prevent hydrolysis and oxidation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.