Description

Ethyl 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern organic synthesis, particularly in cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality precursors for drug discovery and development.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl frameworks, which are core structures in many active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the synthesis of complex molecules for drug discovery programs targeting various therapeutic areas.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, liquid crystals, and light-emitting materials for electronic devices.
• Chemical Biology & Probe Development: Utilized for labeling and modifying biomolecules in research applications.
• Custom Synthesis & Contract Manufacturing: A starting material for bespoke chemical synthesis services for clients in R&D and pilot-scale production.

Basic Information

Item	Details
Product Name	Ethyl 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
CAS No.	474709-72-3
Molecular Formula	C15H20BFO4
Molecular Weight	294.13 g/mol
Synonyms	2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid ethyl ester; Ethyl 2-fluoro-4-(pinacolatoboron)benzoate; 4-(Pinacolatoboran-2-yl)-2-fluorobenzoic acid ethyl ester; 2-Fluoro-4-(pinacolboronato)benzoic acid ethyl ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluorobenzoic acid ethyl ester; 474709-72-3; Ethyl 2-fluoro-4-(pinacolboronate)benzoate
EINECS	Contact for details

Quality Control

Our Ethyl 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.