Description

2,3,3-Trimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-indole is a high-value, synthetically versatile indole-based boronic ester building block. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern organic synthesis for constructing complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the efficient synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in creating complex heterocyclic cores prevalent in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific indole-based structures.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular engineering is required.
• Chemical Biology & Probe Development: Serves as a precursor for creating molecular probes and tags used in biochemical assays and diagnostic research.
• Academic & Industrial R&D: A fundamental reagent in synthetic chemistry laboratories for methodological development and the construction of complex, functionalized indole derivatives.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.

Basic Information

Item	Detail
Product Name	2,3,3-Trimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-indole
CAS No.	473437-34-2
Molecular Formula	C₁₇H₂₄BNO₂
Molecular Weight	285.19 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3,3-trimethyl-1H-indole; 2,3,3-Trimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 2,3,3-Trimethylindole-5-boronic acid pinacol ester; 5-Borono-2,3,3-trimethylindole, pinacol ester; 473437-34-2; (2,3,3-Trimethyl-3H-indol-5-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 2,3,3-Trimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-indole undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), identity (NMR, IR), and impurity profiles. Our quality management system supports traceability and compliance with cGMP standards where applicable for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.