Description

(6-Bromo-2,3-Difluorophenyl)Trimethylsilane is a high-purity organosilicon intermediate featuring a bromo-difluorophenyl moiety. This compound is valued for its role as a versatile building block in advanced organic synthesis, particularly in cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex molecules in drug discovery and development, especially for candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the preparation of novel herbicides, fungicides, and insecticides that require the incorporation of halogenated aromatic systems.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Negishi couplings to form biaryl structures.
• Fluorine Chemistry Research: The difluoro substitution pattern is valuable for studying structure-activity relationships and modulating lipophilicity in bioactive compounds.
• Chemical Derivatization: The trimethylsilyl group can act as a protecting group or be further functionalized, offering additional synthetic handles.

Basic Information

Item	Details
Product Name	(6-Bromo-2,3-Difluorophenyl)Trimethylsilane
CAS No.	473417-24-2
Molecular Formula	C9H11BrF2Si
Molecular Weight	265.17 g/mol
Synonyms	1-Bromo-2,3-difluoro-6-(trimethylsilyl)benzene; Trimethyl(6-bromo-2,3-difluorophenyl)silane; 2,3-Difluoro-6-bromophenyltrimethylsilane; (6-Bromo-2,3-difluorophenyl)(trimethyl)silane; Silane, trimethyl(6-bromo-2,3-difluorophenyl)-; 6-Bromo-2,3-difluorophenyltrimethylsilane
EINECS	Contact for details

Quality Control

Our (6-Bromo-2,3-Difluorophenyl)Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.