Description

4-(2-Bromo-1,1-Difluoroethyl)Bromobenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. This compound matters for its unique molecular architecture, featuring both bromine and difluoroethyl groups, which enables precise structural modifications in complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic motifs for bioactivity or as a handle for further functionalization.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluoroethyl and bromo substituents contribute to metabolic stability and binding affinity.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating halogenated cores in advanced electronic and photonic materials, influencing molecular polarity and mesomorphic properties.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl systems.
• Fluorine Chemistry: The gem-difluoroethyl group provides a valuable source of fluorine atoms for studying structure-activity relationships (SAR) and improving compound lipophilicity and membrane permeability.
• Polymer Modification: Employed as a monomer or functionalizing agent to introduce halogenated aromatic units into polymer backbones, altering thermal and chemical resistance.

Basic Information

Product Name	4-(2-Bromo-1,1-Difluoroethyl)Bromobenzene
CAS No.	471246-90-9
Molecular Formula	C8H6Br2F2
Molecular Weight	307.94 g/mol
Synonyms	1-Bromo-4-(2-bromo-1,1-difluoroethyl)benzene; p-(2-Bromo-1,1-difluoroethyl)bromobenzene; 4-(2-Bromo-1,1-difluoroethyl)phenyl bromide; [2-Bromo-1-(4-bromophenyl)-2,2-difluoroethyl]benzene (incorrect but common misnomer); 1,4-Bis(bromodifluoroethyl)benzene (related compound); BDFB (abbreviation); (4-Bromophenyl)(2-bromo-1,1-difluoroethyl)benzene
EINECS	Contact for details

Quality Control

Our 4-(2-Bromo-1,1-Difluoroethyl)Bromobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.