Description

4-(4-tert-Butoxycarbonylpiperazinyl)Phenylboronic Acid, Pinacol Ester is a high-value, protected boronic ester derivative designed for advanced organic synthesis. This compound is a critical building block in modern pharmaceutical and agrochemical research, enabling the formation of carbon-carbon bonds under mild conditions via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those containing arylpiperazine pharmacophores.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-tolerant boronic ester reagent for palladium-catalyzed coupling with aryl/heteroaryl halides.
• Medicinal Chemistry & Drug Discovery: Used in library synthesis and lead optimization for creating novel compounds with potential therapeutic activity.
• Agrochemical Research: Employed in the development of new crop protection agents and pesticides.
• Material Science: A building block for creating functional organic materials and polymers with specific electronic properties.
• Chemical Biology: Useful for bioconjugation and the synthesis of molecular probes.

Basic Information

Product Name	4-(4-tert-Butoxycarbonylpiperazinyl)Phenylboronic Acid, Pinacol Ester
CAS No.	470478-90-1
Molecular Formula	C21H33BN2O4
Molecular Weight	388.31 g/mol
Synonyms	1-Boc-4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine; 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzeneboronic acid pinacol ester; 1-Boc-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine; 4-(N-Boc-piperazinyl)phenylboronic acid pinacol ester; tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 4-(4-tert-Butoxycarbonylpiperazinyl)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.