Description

(E)-tert-Butyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Allylcarbamate is a high-value, protected amino acid derivative featuring a versatile pinacol boronate ester group. This compound is a critical advanced pharmaceutical intermediate (API intermediate) and a key building block in modern synthetic chemistry, enabling efficient carbon-carbon bond formation. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a pivotal boronic ester reagent for introducing the protected amino allyl fragment into complex molecules, enabling the synthesis of novel drug candidates and bioactive compounds.
• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for oncology, antiviral, and central nervous system (CNS) targeted therapies.
• Peptidomimetics & Conjugate Synthesis: Used in the design and synthesis of peptide analogs and antibody-drug conjugates (ADCs), where its reactive handles allow for precise bioconjugation.
• Agrochemical Research: Employed in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science & Polymer Chemistry: Facilitates the synthesis of functionalized monomers and polymers with tailored properties for electronic or specialty material applications.
• Chemical Biology & Probe Development: Acts as a versatile handle for labeling and modifying biomolecules in proteomics and diagnostic assay development.

Basic Information

Product Name	(E)-tert-Butyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Allylcarbamate
CAS No.	468060-28-8
Molecular Formula	C14H26BNO4
Molecular Weight	283.18 g/mol
Synonyms	Boc-Protected 3-Boron allylglycine pinacol ester; tert-Butyl N-[(1E)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)prop-2-en-1-yl]carbamate; (E)-Boc-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)allylamine; (E)-3-(Boc-amino)-1-propenylboronic acid pinacol ester; 2-[(2E)-3-[(tert-Butoxycarbonyl)amino]prop-1-en-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Allylcarbamic acid, N-Boc-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, (E)-; BOC-3-Boronoallylglycine Pinacol Ester
EINECS	Contact for details

Quality Control

Our (E)-tert-Butyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Allylcarbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, and 11B), and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z ratio by HPLC)	≥ 95:5 (E:Z)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.