Description

3-(2,2-Difluoroethoxy)Benzaldehyde is a high-purity aromatic aldehyde building block featuring a difluoroethoxy substituent, offering unique electronic and steric properties for advanced synthesis. This compound is critical for research and development in pharmaceutical and agrochemical chemistry, where its structure enables the creation of novel molecules with enhanced biological activity and metabolic stability. It is primarily sought by process chemists and R&D teams in the fine chemical, pharmaceutical intermediate, and advanced material sectors for constructing complex target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoroethoxy group can improve lipophilicity and systemic activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorine-containing aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs) due to its modifiable aldehyde functionality.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom chemical synthesis services and scale-up projects under cGMP or ISO quality systems.

Basic Information

Product Name	3-(2,2-Difluoroethoxy)Benzaldehyde
CAS No.	467458-98-6
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	m-(2,2-Difluoroethoxy)benzaldehyde; 3-(2,2-Difluoroethoxy)benzaldehyde; Benzaldehyde, 3-(2,2-difluoroethoxy)-; 2,2-Difluoroethoxybenzene-3-carboxaldehyde; 3-DFEB; (3-Formylphenoxy)-1,1-difluoroethane
EINECS	Contact for details

Quality Control

Our 3-(2,2-Difluoroethoxy)Benzaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, GC, NMR, and IR spectroscopy. Our quality commitment aligns with ICH guidelines, and we support development from research quantities to commercial scale under appropriate quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.