Description

3-o-(2'E,4'E-Decadienoyl)Ingenol CAS NO 466663-11-6 is a specific, semi-synthetic ingenol derivative, a compound of significant interest in advanced pharmaceutical research and development. This molecule is valued for its role as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel therapeutic agents, particularly in oncology and dermatology. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in the discovery and production of innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug candidates targeting specific biological pathways.
• Oncology Research: Investigated for its potential as a core structure in developing novel chemotherapeutic and targeted cancer therapies.
• Dermatological Drug Development: Used in R&D for creating new treatments for skin conditions, leveraging the bioactivity profile of ingenol derivatives.
• Chemical Biology & Probe Development: Employed as a molecular tool to study protein function and cellular signaling mechanisms in academic and industrial research settings.
• Preclinical & Clinical Trial Material: Supplied as a high-purity compound for use in animal studies and the manufacture of batches for early-phase human clinical trials.
• Process Chemistry & Scale-Up: Used by process chemists to develop and optimize robust, scalable synthetic routes for commercial manufacturing.

Basic Information

Product Name	3-o-(2'E,4'E-Decadienoyl)Ingenol
CAS No.	466663-11-6
Molecular Formula	C30H40O6
Molecular Weight	496.64 g/mol
Synonyms	Ingenol 3-(2E,4E-Decadienoate); Ingenol decadienoate; (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-Dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl (2E,4E)-deca-2,4-dienoate; 3-O-[(2E,4E)-2,4-Decadienoyl]ingenol; PEP005 derivative; Ingenol-3-angelate analog
EINECS	Contact for details

Quality Control

Our 3-o-(2'E,4'E-Decadienoyl)Ingenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at -20°C or below for long-term stability. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.