Description

4-Amino-3-Methoxyphenylboronic Acid, Pinacol Ester is a protected boronic acid derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its enhanced stability compared to the free boronic acid, making it an ideal reagent for Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to construct complex biaryl and heterobiaryl scaffolds for active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those containing complex aryl-aryl linkages via palladium-catalyzed cross-coupling.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific biaryl structures for bioactivity.
• Material Science: Serves as a monomer or building block for creating advanced organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology: Utilized in the synthesis of probes and molecular tools for studying biological systems and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Amino-3-Methoxyphenylboronic Acid, Pinacol Ester
CAS No.	461699-81-0
Molecular Formula	C13H20BNO3
Molecular Weight	249.12 g/mol
Synonyms	2-(4-Amino-3-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 4-Amino-3-methoxybenzeneboronic acid pinacol ester; (4-Amino-3-methoxyphenyl)boronic acid pinacol ester; 3-Methoxy-4-aminophenylboronic acid pinacol ester; Boronic acid, B-(4-amino-3-methoxyphenyl)-, 1,1-dimethylethyl ester; 4-Amino-3-methoxybenzeneboronic acid, pinanediol ester (common alternative); 2-(4-Amino-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (IUPAC-style name)
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Methoxyphenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance for sensitive cross-coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.