Description

3-Chloro-4-Pyridineboronic Acid Hydrate is a versatile and high-value boronic acid derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling the precise construction of complex molecules through metal-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require the pyridine scaffold.
• Material Science: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D labs for exploring new C-C bond formation methodologies and creating compound libraries.
• Ligand Synthesis: Can be utilized to prepare novel bidentate or tridentate ligands for catalysis and coordination chemistry.

Basic Information

Product Name	3-Chloro-4-Pyridineboronic Acid Hydrate
CAS No.	458532-98-4
Molecular Formula	C5H5BClNO3 (anhydrous basis)
Molecular Weight	173.36 g/mol (anhydrous basis)
Synonyms	(3-Chloro-4-pyridinyl)boronic acid hydrate; 3-Chloro-4-pyridineboronic acid; 3-Chloro-4-pyridylboronic acid; 4-Borono-3-chloropyridine; 3-Chloro-4-pyridinylboronic acid; Boronic acid, B-(3-chloro-4-pyridinyl)-, hydrate; 3-Chloro-4-pyridineboronic acid monohydrate
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-Pyridineboronic Acid Hydrate is produced and tested under strict quality management protocols. We ensure compliance with relevant industry standards for fine chemicals and pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (anhydrous basis)
Water Content (KF)	≤3.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Soluble in common organic solvents (e.g., DMF, DMSO, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.