Description

2-Chloro-4-Pyridylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters for its critical role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to create novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyridine-based scaffolds.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and other functionalized pyridine derivatives.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for forming carbon-carbon bonds between aromatic and heteroaromatic systems.
• Chemical Biology Probes: Useful in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Scale-up Process Development: Supplied for optimization and pilot-scale synthesis in process chemistry, supporting transition from lab to production.

Basic Information

Product Name	2-Chloro-4-Pyridylboronic Acid
CAS No.	458532-96-2
Molecular Formula	C5H5BClNO2
Molecular Weight	157.36 g/mol
Synonyms	(2-Chloropyridin-4-yl)boronic Acid; 2-Chloro-4-pyridineboronic Acid; 4-Borono-2-chloropyridine; 2-Chloro-4-pyridinylboronic Acid; 2-Chloro-4-pyridylboronic acid pinacol ester (common derivative); 2-Chloro-4-boronopyridine; B-(2-Chloro-4-pyridinyl)boronic Acid
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Pyridylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with full analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical grades: 95%, 97%, 98%, 99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.