Description

3-Chloro-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Pyridine is a high-value organoboron building block, specifically a pyridine boronic ester, essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon and carbon-heteroatom bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized pyridine cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific halogenated heterocyclic structures.
• Material Science: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and charge-transport materials.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 3-chloro-4-pyridyl moiety into target molecules.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological systems and protein interactions.
• Ligand Synthesis: Acts as a starting material for the preparation of complex nitrogen-containing ligands used in catalysis.

Basic Information

Product Name	3-Chloro-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Pyridine
CAS No.	458532-90-6
Molecular Formula	C11H15BClNO2
Molecular Weight	239.51 g/mol
Synonyms	3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-(3-Chloropyridin-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-pyridineboronic acid pinacol ester; 3-Chloro-4-(pinacolatoboryl)pyridine; 4,4,5,5-Tetramethyl-2-(3-chloro-4-pyridinyl)-1,3,2-dioxaborolane; 3-Chloro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Chloro-4-(pinacol boronate)pyridine; 458532-90-6.
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency suitable for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.