Description

(4-[4-(tert-Butoxycarbonyl)Piperazin-1-Yl]Phenyl)Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a boronic acid functional group protected by a Boc (tert-butoxycarbonyl) group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through efficient cross-coupling reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.

Application

This versatile boronic acid derivative is a key reagent in organic synthesis, with primary applications in:

• Pharmaceutical Research & Development: As a crucial building block in Suzuki-Miyaura cross-coupling reactions for constructing biaryl structures found in many drug candidates.
• API (Active Pharmaceutical Ingredient) Synthesis: For the scalable production of complex molecules, including kinase inhibitors and other targeted therapeutics.
• Medicinal Chemistry: Enabling rapid parallel synthesis and structure-activity relationship (SAR) studies due to its stability and reactivity.
• Chemical Biology: Used in the development of molecular probes and bio-conjugates.
• Process Chemistry: Serves as an intermediate in the optimization and scale-up of synthetic routes for commercial drug manufacturing.

Basic Information

Product Name	(4-[4-(tert-Butoxycarbonyl)Piperazin-1-Yl]Phenyl)Boronic Acid
CAS No.	457613-78-4
Molecular Formula	C15H23BN2O4
Molecular Weight	306.17 g/mol
Synonyms	4-(4-Boc-Piperazin-1-yl)benzeneboronic acid; 1-Boc-4-(4-boronophenyl)piperazine; 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)phenylboronic acid; 4-(N-Boc-piperazinyl)phenylboronic acid; [4-(4-Boc-piperazin-1-yl)phenyl]boronic acid; 4-(4-Boc-1-piperazinyl)benzeneboronic acid; B-[4-[4-[(1,1-Dimethylethoxy)carbonyl]-1-piperazinyl]phenyl]boronic acid
EINECS	Contact for details

Quality Control

Our (4-[4-(tert-Butoxycarbonyl)Piperazin-1-Yl]Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed HPLC, NMR, and mass spectrometry data are provided to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.