Description

Cyclopropanecarboxamide, n-(trans-4-Ethylcyclohexyl)-2-(Hydroxymethyl)-, (1R,2R)-Rel- (9Ci) CAS NO 452911-13-6 is a high-purity, stereochemically defined chiral compound belonging to the cyclopropane carboxamide class. This molecule is of significant commercial interest as a sophisticated pharmaceutical intermediate or advanced research chemical for drug discovery programs. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams requiring specific stereochemistry for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel therapeutic agents, particularly where the rigid cyclopropane and chiral cyclohexyl motifs are required for biological activity.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and as a precursor for targeted libraries.
• Chiral Catalyst or Ligand Precursor: Potential starting material for the development of asymmetric synthesis catalysts due to its defined stereocenters.
• Advanced Organic Synthesis: Serves as a specialized synthon for constructing complex molecular architectures in academic and industrial research settings.
• Biochemical Probe Development: Can be utilized to create probes for studying enzyme mechanisms or receptor interactions.

Basic Information

Product Name	Cyclopropanecarboxamide, n-(trans-4-Ethylcyclohexyl)-2-(Hydroxymethyl)-, (1R,2R)-Rel- (9Ci)
CAS No.	452911-13-6
Molecular Formula	C13H23NO2
Molecular Weight	225.33 g/mol
Synonyms	(1R,2R)-N-[(trans)-4-Ethylcyclohexyl]-2-(hydroxymethyl)cyclopropanecarboxamide; rel-(1R,2R)-N-(trans-4-Ethylcyclohexyl)-2-(hydroxymethyl)cyclopropanecarboxamide; (1R,2R)-N-(trans-4-Ethylcyclohexyl)-2-(hydroxymethyl)cyclopropanecarboxamide (rel); trans-N-(4-Ethylcyclohexyl)-2-(hydroxymethyl)cyclopropanecarboxamide (1R,2R)-isomer; Cyclopropanecarboxamide, N-(trans-4-ethylcyclohexyl)-2-(hydroxymethyl)-, (1R,2R)-rel-; 452911-13-6
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high stereochemical purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, GC, and NMR. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.