Description

2-Bromo-4-Chloro-1-(2,2,2-Trifluoroethoxy)-Benzene is a high-purity halogenated aromatic ether building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique trifluoroethoxy and halogen substituents enable precise structural modifications. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, especially in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated aromatic components used in electronic display technologies.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce functionalized aryl groups.
• Chemical Research & Development: Essential for academic and industrial labs exploring new synthetic methodologies and novel fluorinated compounds.
• Specialty Polymer Modification: Acts as a monomer or modifier to incorporate fluorine and halogen atoms into polymer backbones, enhancing material properties.

Basic Information

Product Name	2-Bromo-4-Chloro-1-(2,2,2-Trifluoroethoxy)-Benzene
CAS No.	452082-66-5
Molecular Formula	C8H5BrClF3O
Molecular Weight	289.48 g/mol
Synonyms	1-Bromo-3-Chloro-4-(2,2,2-Trifluoroethoxy)Benzene; 2-Bromo-4-Chlorophenyl 2,2,2-Trifluoroethyl Ether; 4-Chloro-2-bromo-1-(2,2,2-trifluoroethoxy)benzene; Benzene, 2-bromo-4-chloro-1-(2,2,2-trifluoroethoxy)-; 2-Bromo-4-chloro-α,α,α-trifluorophenetole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of 2-Bromo-4-Chloro-1-(2,2,2-Trifluoroethoxy)-Benzene is analyzed using advanced techniques like HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. We adhere to a strict quality management system and provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Specifications can be aligned with cGMP or other relevant regulatory frameworks upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed in a dry and well-ventilated place. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Standard Grade)
Purity (GC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.