Description

4-[2-(4-Chloro-3-Fluorophenoxy)Phenyl]-3-Buten-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated diaryl ether structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in research and development pipelines targeting complex therapeutic areas. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to build sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those with halogenated aromatic systems.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides where the chlorinated and fluorinated phenoxy moiety is biologically active.
• Material Science Precursor: Serves as a monomer or precursor for synthesizing specialized polymers or liquid crystals with unique optical or electronic properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, such as Heck or Suzuki reactions, due to the reactive olefin and aryl halide functionalities present in its structure.
• Chemical Biology Probe Development: Utilized to create molecular probes for studying enzyme function or protein-ligand interactions in biochemical research.

Basic Information

Product Name	4-[2-(4-Chloro-3-Fluorophenoxy)Phenyl]-3-Buten-2-One
CAS No.	451485-73-7
Molecular Formula	C₁₆H₁₂ClFO₂
Molecular Weight	290.72 g/mol
Synonyms	4-[2-(4-Chloro-3-fluorophenoxy)phenyl]but-3-en-2-one; 3-Buten-2-one, 4-[2-(4-chloro-3-fluorophenoxy)phenyl]-; (E)-4-(2-(4-Chloro-3-fluorophenoxy)phenyl)but-3-en-2-one; 1-(2-(4-Chloro-3-fluorophenoxy)phenyl)prop-2-en-1-one (tautomeric form); 4-(2-(4-Chloro-3-fluorophenoxy)phenyl)-3-buten-2-one; CAS 451485-73-7
EINECS	Contact for details

Quality Control

Our 4-[2-(4-Chloro-3-Fluorophenoxy)Phenyl]-3-Buten-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This material may be light-sensitive; prolonged exposure to light should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.