Description

(Z)-(4-Ethoxy-4-Oxo-2-Buten-2-Yl)Boronic Acid Pinacol Ester is a high-purity, advanced boronic ester building block crucial for modern synthetic chemistry. Its primary value lies in enabling efficient, selective cross-coupling reactions, particularly Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery, catalyst development, and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for complex, targeted molecules.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical organoboron reagent for forming carbon-carbon bonds between aromatic and alkenyl systems under mild conditions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific structural motifs.
• Ligand and Catalyst Development: Employed in the creation of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Material Science Research: A precursor for developing organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Synthesis: Useful for creating molecular probes and bioconjugates for studying biological processes and target engagement.

Basic Information

Product Name	(Z)-(4-Ethoxy-4-Oxo-2-Buten-2-Yl)Boronic Acid Pinacol Ester
CAS No.	448212-00-8
Molecular Formula	C₁₂H₂₁BO₄
Molecular Weight	240.11 g/mol
Synonyms	(Z)-4-Ethoxy-4-oxobut-2-en-2-ylboronic acid pinacol ester; (Z)-2-(4-Ethoxy-4-oxobut-2-en-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (Z)-2-(4-Ethoxy-1,4-dioxobut-2-en-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (Z)-Ethyl 3-borono-2-methylacrylate pinacol ester; (Z)-Ethyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methylacrylate; (Z)-Ethyl 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acrylate; (Z)-Boronic acid, B-(4-ethoxy-1,4-dioxo-2-buten-2-yl)-, pinacol ester
EINECS	Contact for details

Quality Control

Our (Z)-(4-Ethoxy-4-Oxo-2-Buten-2-Yl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.