Description

1-Bromo-4-(Chloromethyl)-2,5-Dimethoxybenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional reactivity, featuring both bromine and chloromethyl substituents on a dimethoxybenzene core, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and industrial R&D departments engaged in pharmaceutical development, agrochemical synthesis, and the creation of specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules with complex aryl-ether or substituted benzene motifs.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and other crop protection agents where its halogenated structure allows for further functionalization.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the creation of monomers or cross-linking agents for advanced polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags due to its reactive handles that can be used for bioconjugation.
• Custom Synthesis and Scale-Up: A valuable substrate for contract research organizations (CROs) and custom synthesis manufacturers serving the fine chemical industry.

Basic Information

Product Name	1-Bromo-4-(Chloromethyl)-2,5-Dimethoxybenzene
CAS No.	446831-24-9
Molecular Formula	C9H10BrClO2
Molecular Weight	265.53 g/mol
Synonyms	2,5-Dimethoxy-4-bromobenzyl chloride; 4-Bromo-2,5-dimethoxybenzyl chloride; 1-Bromo-4-(chloromethyl)-2,5-dimethoxybenzene; (4-Bromo-2,5-dimethoxyphenyl)methyl chloride; 4-Bromo-α-chloro-2,5-dimethoxytoluene
EINECS	Contact for details

Quality Control

Our production of 1-Bromo-4-(Chloromethyl)-2,5-Dimethoxybenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.