Description

Ethyl 2-(2-((3-Cyano-4,6-Dimethylpyridin-2-Yl)Thio)Acetamido)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of new drug candidates.
• API Synthesis: Serves as a core building block for constructing complex molecules with potential biological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes.
• Contract Manufacturing: Supplied to CDMOs for scale-up and cGMP production of clinical trial materials.
• Chemical Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	Ethyl 2-(2-((3-Cyano-4,6-Dimethylpyridin-2-Yl)Thio)Acetamido)-5,6-Dihydro-4H-Cyclopenta[B]Thiophene-3-Carboxylate
CAS No.	445382-95-6
Molecular Formula	C22H22N4O3S2
Molecular Weight	454.56 g/mol
Synonyms	2-[[2-[(3-Cyano-4,6-dimethyl-2-pyridinyl)thio]acetyl]amino]-4,5,6,7-tetrahydro-3-thiophenecarboxylic acid ethyl ester; Ethyl 2-(2-((3-cyano-4,6-dimethylpyridin-2-yl)thio)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate; 445382-95-6; CAS 445382-95-6
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, GC, and NMR. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development and cGMP requirements, with specifications tailored to client needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.