Description

2-(4-Chloro-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in its role as a versatile intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality reagents for Suzuki-Miyaura coupling and other palladium-catalyzed transformations.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require specific aryl-chloro substitution patterns.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the synthesis of novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tagged molecules and bioconjugates for imaging, diagnostics, and proteomics studies.
• Custom Synthesis and R&D: A fundamental reagent for contract research organizations (CROs) and academic laboratories exploring new synthetic methodologies.

Basic Information

Product Name	2-(4-Chloro-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	445303-11-7
Molecular Formula	C13H18BClO2
Molecular Weight	252.54 g/mol
Synonyms	4-Chloro-3-methylbenzeneboronic acid pinacol ester; (4-Chloro-3-methylphenyl)boronic acid pinacol ester; 2-(4-Chloro-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-3-methylphenylboronic acid pinacol ester; 1-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methylbenzene; 445303-11-7; Pinacol (4-chloro-3-methylphenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-(4-Chloro-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent hydrolysis and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.