Description

2-(3-Chloro-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a crucial organoboron building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, ligand synthesis, and functional polymer development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or substituted phenyl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific chlorinated and methylated aromatic structures.
• Material Science: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs, OFETs, and conductive polymers.
• Ligand & Catalyst Preparation: Employed to create sophisticated bidentate or monodentate ligands for transition metal catalysis and asymmetric synthesis.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new C-C bond-forming reactions and constructing molecular libraries.
• Fine Chemical Production: Integral to the multi-step synthesis of complex fragrances, dyes, and other specialty chemicals.

Basic Information

Product Name	2-(3-Chloro-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	445303-10-6
Molecular Formula	C13H18BClO2
Molecular Weight	252.54 g/mol
Synonyms	(3-Chloro-4-methylphenyl)boronic acid pinacol ester; 2-(3-Chloro-p-tolyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-methylbenzeneboronic acid pinacol ester; Pinacol (3-chloro-4-methylphenyl)boronate; (3-Chloro-4-methylphenyl)BPin; CAS 445303-10-6; B-(3-Chloro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(3-Chloro-4-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reproducible results and regulatory compliance in demanding fields like pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.