Description

4-Chloro-3-Trifluoromethylphenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid form, which is critical for reliable performance in sensitive synthetic workflows. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for creating novel active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require the specific 4-chloro-3-(trifluoromethyl)phenyl moiety.
• Material Science: Serves as a monomer or precursor in the synthesis of advanced organic electronic materials, such as those used in OLEDs or organic semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for studying biological systems.
• Custom Synthesis & Contract Manufacturing: An essential reagent for fine chemical suppliers offering bespoke synthesis services to the life sciences sector.
• Academic Research: A valuable tool in university and institutional laboratories for methodological development in synthetic organic chemistry.

Basic Information

Product Name	4-Chloro-3-Trifluoromethylphenylboronic Acid, Pinacol Ester
CAS No.	445303-09-3
Molecular Formula	C13H15BClF3O2
Molecular Weight	306.52 g/mol
Synonyms	4-Chloro-3-(trifluoromethyl)benzeneboronic Acid Pinacol Ester; 2-(4-Chloro-3-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-Chloro-3-(trifluoromethyl)phenyl)boronic Acid Pinacol Ester; 4-Chloro-α,α,α-trifluoro-m-tolylboronic Acid Pinacol Ester; Pinacol (4-Chloro-3-(trifluoromethyl)phenyl)boronate; CAS 445303-09-3
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-3-Trifluoromethylphenylboronic Acid, Pinacol Ester is produced under strict quality management protocols. Our products undergo rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.