Description

2-Methoxypyridine-5-Boronic Acid Pinacol Ester is a high-value organoboron building block essential for modern synthetic chemistry. This compound is a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid form. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures via cross-coupling reactions.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, enabling the synthesis of biaryl and heterobiaryl structures prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Serves as a critical precursor in the development of drug candidates, particularly those containing functionalized pyridine moieties for oncology, CNS, and antiviral therapies.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks for bioactivity.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, ligands for catalysts, and electron-transport materials for electronic devices.
• Chemical Biology & Probe Development: Useful for tagging and modifying biomolecules or creating chemical probes for biological target identification.

Basic Information

Product Name	2-Methoxypyridine-5-Boronic Acid Pinacol Ester
CAS No.	445264-61-9
Molecular Formula	C₁₃H₂₀BNO₃
Molecular Weight	249.12 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxypyridine; 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Methoxypyridin-5-ylboronic acid pinacol ester; 5-Borono-2-methoxypyridine pinacol ester; (2-Methoxypyridin-5-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 2-Methoxypyridine-5-Boronic Acid Pinacol Ester is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical synthesis work. We employ advanced analytical techniques including NMR, HPLC, and GC-MS for identity confirmation and purity verification. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.