Description

3-Methoxypyridine-5-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound matters as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily needed by pharmaceutical R&D teams, agrochemical manufacturers, and advanced material scientists for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound libraries.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs and charge-transport molecules.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Catalyst Ligand Development: Utilized to construct novel ligand frameworks for transition metal catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	3-Methoxypyridine-5-Boronic Acid Pinacol Ester
CAS No.	445264-60-8
Molecular Formula	C₁₂H₁₈BNO₃
Molecular Weight	235.09 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methoxypyridine; (3-Methoxypyridin-5-yl)boronic acid pinacol ester; 3-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Methoxy-5-pyridineboronic acid pinacol ester; 5-Borono-3-methoxypyridine pinacol ester; 3-Methoxy-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Methoxypyridine-5-boronic acid neopentyl glycol ester (common alternative); PINACOL 3-METHOXYPYRIDINE-5-BORONATE
EINECS	Contact for details

Quality Control

Our 3-Methoxypyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with ISO standards and meets the stringent requirements for pharmaceutical R&D and scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.