Description

Benzene, 4-(Chloromethyl)-2-Fluoro-1-(Trifluoromethyl)- is a highly functionalized aromatic compound, distinguished by its unique combination of chloromethyl, fluoro, and trifluoromethyl substituents. This molecular architecture makes it a versatile and critical building block for advanced chemical synthesis, particularly in the development of complex molecules with tailored properties. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring fluorinated and halogenated benzene cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl and fluoro groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific characteristics such as chemical resistance, thermal stability, or altered surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a scaffold for constructing more complex polyfunctional aromatic systems in academic and industrial research.

Basic Information

Item	Details
Product Name	Benzene, 4-(Chloromethyl)-2-Fluoro-1-(Trifluoromethyl)-
CAS No.	444915-54-2
Molecular Formula	C9H5ClF4
Molecular Weight	224.58 g/mol
Synonyms	1-(Chloromethyl)-4-fluoro-3-(trifluoromethyl)benzene; 4-(Chloromethyl)-2-fluoro-α,α,α-trifluorotoluene; 2-Fluoro-α,α,α-trifluoro-4-(chloromethyl)toluene; 4-(Chloromethyl)-2-fluoro-1-(trifluoromethyl)benzene; 2-Fluoro-4-(chloromethyl)benzotrifluoride; 4-Fluoro-3-(trifluoromethyl)benzyl chloride; (4-Fluoro-3-(trifluoromethyl)phenyl)methyl chloride
EINECS	Contact for details

Quality Control

Our production of Benzene, 4-(Chloromethyl)-2-Fluoro-1-(Trifluoromethyl)- adheres to a stringent quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under GMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Density	~1.45 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.