Description

Methyl (2R)-2-Amino-3-(4-Fluorophenyl)Propanoate is a high-purity, chiral amino acid ester derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined, fluorinated phenylalanine backbone essential for constructing complex molecules with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated peptide-based drugs and protease inhibitors.
• API Development: Used in research and process chemistry for constructing novel Active Pharmaceutical Ingredients (APIs) targeting neurological and metabolic disorders.
• Peptidomimetics: Serves as a constrained amino acid analog in the design of stable peptide mimics with enhanced bioavailability.
• Chemical Biology Probes: Incorporation into fluorescent or affinity tags for studying protein-protein interactions and enzyme mechanisms.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric transformations to introduce chirality.
• Material Science Research: Potential monomer for specialized polymers or coatings where fluorinated aromatic groups impart specific properties.

Basic Information

Product Name	Methyl (2R)-2-Amino-3-(4-Fluorophenyl)Propanoate
CAS No.	444583-22-6
Molecular Formula	C10H12FNO2
Molecular Weight	197.21 g/mol
Synonyms	(R)-Methyl 2-amino-3-(4-fluorophenyl)propanoate; D-4-Fluorophenylalanine methyl ester; (R)-4-F-Phe-OMe; Methyl (R)-2-amino-3-(4-fluorophenyl)propionate; (2R)-2-Amino-3-(4-fluorophenyl)propanoic acid methyl ester; L-4-Fluorophenylalanine methyl ester (enantiomer); 4-Fluoro-D-phenylalanine methyl ester; Fmoc-4-F-D-Phe-OMe (protected form)
EINECS	Contact for details

Quality Control

Our Methyl (2R)-2-Amino-3-(4-Fluorophenyl)Propanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. Due to its hygroscopic nature, the container should be kept in a desiccated environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.