Description

1-Bromo-2-(1,1-Difluoroethyl)Benzene is a high-value, multi-functional aromatic building block characterized by its bromine and difluoroethyl substituents, offering unique reactivity for advanced synthesis. This compound is essential for research and development in modern pharmaceutical and agrochemical discovery, where its structure enables precise molecular modifications. It is primarily sought after by fine chemical manufacturers and R&D laboratories specializing in the creation of novel active ingredients and complex organic materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aromatic motifs to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoroethyl group can improve efficacy and environmental profile.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials requiring specific halogenated and fluorinated components.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to construct complex biaryl systems.
• Fluorine Chemistry Studies: An important compound for academic and industrial research exploring the effects of gem-difluoro groups on chemical reactivity and physical properties.

Basic Information

Product Name	1-Bromo-2-(1,1-Difluoroethyl)Benzene
CAS No.	444581-46-8
Molecular Formula	C8H7BrF2
Molecular Weight	221.04 g/mol
Synonyms	2-Bromo-α,α-difluoroethylbenzene; 1-Bromo-2-(1,1-difluoroethyl)benzene; o-Bromo-α,α-difluoroethylbenzene; Benzene, 1-bromo-2-(1,1-difluoroethyl)-; (2-Bromophenyl)difluoroethane; 1-(2-Bromophenyl)-1,1-difluoroethane
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-2-(1,1-Difluoroethyl)Benzene is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.