Description

tert-Butyl 8-Formyl-3,4-Dihydroquinoline-1(2H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a formyl-substituted dihydroquinoline core protected by a tert-butoxycarbonyl (Boc) group. This compound is a critical building block in modern organic synthesis, enabling the precise construction of complex nitrogen-containing heterocycles. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Organic Synthesis Building Block: The reactive formyl group allows for further functionalization via condensation or reduction reactions, making it valuable for constructing diverse chemical libraries.
• Agrochemical Research: Used in the development of new herbicides and pesticides that incorporate the quinoline scaffold for enhanced biological activity.
• Material Science: Investigated as a monomer or ligand precursor for the creation of functional polymers and metal-organic frameworks (MOFs).
• Academic & R&D: Employed in university and industrial research laboratories for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	tert-Butyl 8-Formyl-3,4-Dihydroquinoline-1(2H)-Carboxylate
CAS No.	444188-08-3
Molecular Formula	C15H17NO3
Molecular Weight	259.30 g/mol
Synonyms	1-Boc-8-formyl-1,2,3,4-tetrahydroquinoline; 8-Formyl-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; tert-Butyl 8-formyl-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1,2,3,4-Tetrahydro-8-quinolinecarboxaldehyde, 1-(1,1-dimethylethoxy)carbonyl]-; 1-N-Boc-8-formyl-1,2,3,4-tetrahydroquinoline; Boc-8-CHO-THQ; 444188-08-3
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 8-Formyl-3,4-Dihydroquinoline-1(2H)-Carboxylate adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is fully characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.