Description

2-Chloropyridine-5-Boronic Acid is a versatile and high-value boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced material development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to synthesize complex heterocyclic target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing functionalized pyridine cores for kinase inhibitors and other therapeutic agents.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Building block for constructing organic electronic materials, metal-organic frameworks (MOFs), and functional polymers.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and bioconjugation reagents.
• Catalyst Ligand Synthesis: Serves as a precursor for synthesizing specialized ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloropyridine-5-Boronic Acid
CAS No.	444120-91-6
Molecular Formula	C5H5BClNO2
Molecular Weight	157.36 g/mol
Synonyms	(6-Chloropyridin-3-yl)boronic acid; 5-Borono-2-chloropyridine; 2-Chloro-5-pyridineboronic acid; 2-Chloro-5-boronopyridine; 6-Chloro-3-pyridineboronic acid; 2-Chloropyridin-5-ylboronic acid; 2-Chloro-5-pyridinylboronic Acid; Boronic acid, B-(6-chloro-3-pyridinyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloropyridine-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with full batch traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF Titration)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.