Description

2-(Bromomethyl)-1-Fluoro-4-Iodobenzene, also known as α-Bromo-2-Fluoro-5-Iodotoluene, is a high-value, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromomethyl, fluoro, and iodo substituents on a benzene ring, makes it a versatile and reactive intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science. Precise control over its purity and stability is critical for ensuring reproducible results in downstream synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing halogenated aromatic motifs that can modulate bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the halogen atoms contribute to binding affinity and environmental persistence.
• Material Science Research: Acts as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its ability to undergo various cross-coupling reactions.
• Cross-Coupling Reactions: The bromomethyl and iodo groups are excellent handles for Suzuki, Stille, and Negishi cross-coupling reactions, enabling the construction of complex biaryl and conjugated systems.
• Medicinal Chemistry & Drug Discovery: Utilized in lead optimization and library synthesis to explore structure-activity relationships (SAR) by introducing specific halogen atoms at defined positions on a molecular scaffold.
• Chemical Biology Probes: Can be used to synthesize molecular probes and tags for studying biological processes, leveraging the reactivity of the halogens for bioconjugation.

Basic Information

Product Name	2-(Bromomethyl)-1-Fluoro-4-Iodobenzene
CAS No.	442910-33-0
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	α-Bromo-2-Fluoro-5-Iodotoluene; 1-Bromomethyl-2-fluoro-5-iodobenzene; 2-Fluoro-5-iodobenzyl Bromide; (2-Fluoro-5-iodophenyl)methyl Bromide; 2-Fluoro-α-bromo-5-iodotoluene; 5-Iodo-2-fluorobenzyl Bromide; Benzene, 2-(bromomethyl)-1-fluoro-4-iodo-; Toluene, α-bromo-2-fluoro-5-iodo-
EINECS	Contact for details

Quality Control

Our 2-(Bromomethyl)-1-Fluoro-4-Iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and development applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.