Description

Phosphonic Acid, [[[1-[(2-Amino-9H-Purin-9-Yl)Methyl]Cyclopropyl]Oxy]Methyl]- (9Ci) is a specialized nucleotide analog with a unique cyclopropane-phosphonate backbone, representing a high-value synthetic intermediate in advanced pharmaceutical research. This compound matters for its role as a key building block in the development of novel antiviral and anticancer therapeutics, particularly nucleotide-based prodrugs targeting viral polymerases. Research and development teams in the pharmaceutical and biotechnology sectors need this high-purity intermediate to synthesize and evaluate next-generation therapeutic candidates.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of nucleotide analog prodrugs with antiviral or anticancer activity.
• Antiviral Drug Research: Used in the development of novel therapeutic agents targeting viruses such as hepatitis B (HBV), hepatitis C (HCV), and other viral pathogens.
• Oncology Research: Serves as a precursor for compounds designed to inhibit cancer cell proliferation by interfering with DNA/RNA synthesis.
• Biochemical Tool: Employed in enzymatic studies and as a substrate analog to investigate the mechanisms of polymerases and other nucleic acid-processing enzymes.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to optimize the potency, selectivity, and pharmacokinetic properties of nucleotide-based drugs.
• Pre-clinical Development: Supplied in research quantities for in vitro and in vivo efficacy and toxicity studies of new chemical entities.

Basic Information

Product Name	Phosphonic Acid, [[[1-[(2-Amino-9H-Purin-9-Yl)Methyl]Cyclopropyl]Oxy]Methyl]- (9Ci)
CAS No.	441785-25-7
Molecular Formula	C11H14N5O4P
Molecular Weight	311.23 g/mol
Synonyms	[[[1-[(2-Amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]phosphonic acid; 9-[[1-[[(Phosphonomethyl)oxy]methyl]cyclopropyl]methyl]-9H-purin-2-amine; Cyclopropane Phosphonate Adenine Nucleotide Analog; 2-Amino-9-[(1-{[(phosphonomethyl)oxy]methyl}cyclopropyl)methyl]-1,9-dihydro-6H-purin-6-one; Acyclic Nucleotide Phosphonate Intermediate; cPrPMEDAP analog; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

This high-value pharmaceutical intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for research and development. Our standard grade typically meets a purity specification of ≥95% (by HPLC), with comprehensive characterization including NMR and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development projects requiring custom purity grades or specialized analytical data.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as indicated on the label or CoA. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.