Description

2-[2-(Bromomethyl)Phenyl]-5,5-Dimethyl-1,3,2-Dioxaborinane is a valuable organoboron building block, specifically a protected boronic ester derivative with a reactive bromomethyl handle. This compound matters for its dual functionality, enabling sequential cross-coupling and further functionalization in complex molecule synthesis. It is primarily needed by pharmaceutical and agrochemical R&D departments, as well as advanced material scientists, for constructing novel chemical entities and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of biaryl and heterobiaryl scaffolds prevalent in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides by incorporating the phenyl-dioxaborinane moiety into target molecules.
• Material Science: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs and OFETs.
• Chemical Biology & Probe Development: Utilized for labeling and bioconjugation strategies due to the reactive bromomethyl group, which can be further substituted.
• Ligand & Catalyst Preparation: Acts as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Polymer Chemistry: Incorporated into polymer backbones or as a chain-end modifier to introduce boronic ester functionality for responsive or self-healing materials.

Basic Information

Product Name	2-[2-(Bromomethyl)Phenyl]-5,5-Dimethyl-1,3,2-Dioxaborinane
CAS No.	441011-76-3
Molecular Formula	C₁₃H₁₈BBrO₂
Molecular Weight	297.00 g/mol
Synonyms	2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; (2-(Bromomethyl)phenyl)boronic acid neopentyl glycol ester; 2-(2-Bromobenzyl)-5,5-dimethyl-1,3,2-dioxaborinane; 2-(2-Bromomethylphenyl)-5,5-dimethyl-[1,3,2]dioxaborinane; Bromomethylphenyl Neopentyl Glycol Boronic Ester; 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane; CAS 441011-76-3
EINECS	Contact for details

Quality Control

Our 2-[2-(Bromomethyl)Phenyl]-5,5-Dimethyl-1,3,2-Dioxaborinane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.