Description

2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)benzo[d]oxazole is a high-value, synthetically versatile organoboron building block, specifically a pinacol boronate ester derivative of a benzoxazole fluorophore. This compound is engineered to serve as a critical coupling partner in cross-coupling reactions, enabling the efficient synthesis of complex organic architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecules with tailored electronic and photophysical properties.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key electrophilic coupling partner for the synthesis of biaryl and heterobiaryl systems, essential in drug discovery and material science.
• Pharmaceutical Intermediate: For the construction of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing benzoxazole moieties known for diverse biological activities.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor for electron-transporting or emissive layer materials in display and lighting technologies.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: As a building block for synthesizing novel chelating ligands and organometallic catalysts.
• Polymer and Material Science: Incorporation into conjugated polymers and organic semiconductors to modify electronic properties and processability.
• Fluorescent Probe and Sensor Development: Leveraging the intrinsic fluorescence of the benzoxazole core for creating chemical and biological sensors.
• Academic and Industrial R&D: A fundamental reagent for methodological development in synthetic organic chemistry and exploratory research.

Basic Information

Item	Details
Product Name	2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)benzo[d]oxazole
CAS No.	439090-73-0
Molecular Formula	C21H22BNO3
Molecular Weight	347.22 g/mol
Synonyms	2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,3-benzoxazole; 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzoxazole; 4-(Benzoxazol-2-yl)phenylboronic acid pinacol ester; 2-(4-(Pinacolatoboron)phenyl)benzoxazole; 2-(4-Boronophenyl)benzoxazole pinacol ester; Benzoxazole pinacol boronate; 439090-73-0; BRN 9087555
EINECS	Contact for details

Quality Control

Every batch of 2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)benzo[d]oxazole is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize hydrolysis of the boronate ester. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.