Description

4,4-Difluoroadamantane-1-Carboxylic Acid is a high-value, fluorinated adamantane derivative that serves as a critical building block in advanced organic synthesis. This compound is prized for its unique structural rigidity and the introduction of fluorine atoms, which can dramatically alter the physicochemical and biological properties of target molecules. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for developing new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, antiviral agents, and enzyme inhibitors.
• Agrochemical Research: Used in the synthesis of novel pesticides and herbicides, where the adamantane core and fluorine atoms can enhance stability, bioavailability, and activity.
• Material Science Precursor: Serves as a monomer or functional additive in the creation of specialty polymers, coatings, and advanced organic frameworks (MOFs/COFs) with tailored properties.
• Ligand and Catalyst Development: The carboxylic acid functionality allows for derivatization into complex ligands for catalysis or metal-organic complexes.
• Fluorine Chemistry & SAR Studies: An essential tool for structure-activity relationship (SAR) studies to investigate the "fluorine effect" on potency, metabolic stability, and membrane permeability.
• Academic & Industrial R&D: Employed in fundamental research exploring new synthetic methodologies and the properties of fluorinated cage compounds.

Basic Information

Item	Details
Product Name	4,4-Difluoroadamantane-1-Carboxylic Acid
CAS No.	438017-43-7
Molecular Formula	C11H14F2O2
Molecular Weight	216.23 g/mol
Synonyms	1-Adamantanecarboxylic acid, 4,4-difluoro-; 4,4-Difluoroadamantane-1-carboxylic acid; 4,4-Difluoro-1-adamantanecarboxylic acid; 4,4-Difluorotricyclo[3.3.1.13,7]decane-1-carboxylic acid; 1-Carboxy-4,4-difluoroadamantane; Difluoroadamantanecarboxylic acid
EINECS	Contact for details

Quality Control

Our 4,4-Difluoroadamantane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical specifications. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.