Description

Ethanone, 1-(1,3-Benzodioxol-5-Yl)-2,2-Difluoro- (9Ci) CAS NO 437552-71-1 is a specialized difluorinated acetophenone derivative featuring a 1,3-benzodioxole (methylenedioxyphenyl) moiety. This compound is valued as a key synthetic intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for its unique fluorinated structure which can impart desirable metabolic stability and bioavailability to target molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, especially those targeting the central nervous system (CNS).
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoroacetophenone core enhances biological activity.
• Fine Chemical Production: Serves as a precursor for various specialty chemicals, including flavors, fragrances, and functional materials.
• Organic Synthesis Research: Employed in academic and industrial R&D for methodology development and the construction of complex heterocyclic compounds.
• Ligand and Catalyst Development: The benzodioxole and carbonyl groups make it a useful scaffold for designing novel ligands in catalytic processes.

Basic Information

Product Name	Ethanone, 1-(1,3-Benzodioxol-5-Yl)-2,2-Difluoro- (9Ci)
CAS No.	437552-71-1
Molecular Formula	C9H6F2O3
Molecular Weight	200.14 g/mol
Synonyms	1-(1,3-Benzodioxol-5-yl)-2,2-difluoroethanone; 2,2-Difluoro-1-(1,3-benzodioxol-5-yl)ethanone; 1-(Benzo[d][1,3]dioxol-5-yl)-2,2-difluoroethanone; 5-Acetyl-1,3-benzodioxole-2,2-difluoride; Difluoro(1,3-benzodioxol-5-yl)methanone; 2',4'-Difluoro-3',4'-methylenedioxyacetophenone; CAS 437552-71-1
EINECS	Contact for details

Quality Control

Our Ethanone, 1-(1,3-Benzodioxol-5-Yl)-2,2-Difluoro- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and industrial synthesis. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.