Description

n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-2-Propenamide is a high-purity, advanced pharmaceutical intermediate featuring a reactive acrylamide group and a protected boronic acid pinacol ester. This compound matters because it serves as a critical building block in modern synthetic chemistry, enabling the construction of complex molecules through versatile cross-coupling and polymerization reactions. It is essential for research and development chemists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality precursors for drug discovery and specialty polymer synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Bioconjugation & Probe Development: Used to create fluorescent probes, affinity labels, and bioconjugates, leveraging the reactive acrylamide moiety for Michael addition with thiols.
• Polymer Chemistry: Serves as a functional monomer for creating specialty polymers with boronic acid or amide side chains for sensor or hydrogel applications.
• Agrochemical Synthesis: Employed in the research and development of novel crop protection agents and herbicides.
• Material Science: Used in the development of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Research: Acts as a tool compound for studying protein interactions and enzyme inhibition through its bifunctional reactivity.

Basic Information

Item	Details
Product Name	n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-2-Propenamide
CAS No.	434898-99-4
Molecular Formula	C15H20BNO3
Molecular Weight	273.14 g/mol
Synonyms	4-Acrylamidophenylboronic acid pinacol ester; 2-Propenamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 4-(Acrylamido)phenylboronic acid pinacol ester; N-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acrylamide; Acrylamide-based boronic ester; B-(4-Acrylamidophenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-2-Propenamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with exacting standards for research and development use. Certificates of Analysis (COA) with full batch traceability are provided to guarantee reliable and reproducible performance in your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.