Description

5H-Cyclopropa[G]Pyrrolizine-3-Carboxylicacid,Hexahydro-5-Oxo-,(1Ar,3R,7As)-(9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined cyclopropapyrrolizine core structure. This compound matters as a critical building block for the synthesis of novel, potent active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. Pharmaceutical R&D and process chemistry teams need this high-value intermediate to develop next-generation treatments, leveraging its unique fused ring system to impart specific biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Process Development & Scale-up: Employed in the development and optimization of robust, scalable synthetic routes for GMP manufacturing of APIs.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and research organizations specializing in custom synthesis and early-phase clinical trial material production.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	5H-Cyclopropa[G]Pyrrolizine-3-Carboxylicacid,Hexahydro-5-Oxo-,(1Ar,3R,7As)-(9Ci)
CAS No.	433715-58-3
Molecular Formula	C9H11NO3
Molecular Weight	181.19 g/mol
Synonyms	(1aR,3R,7aS)-Hexahydro-5-oxo-1H-cyclopropa[g]pyrrolizine-3-carboxylic acid; (1aR,3R,7aS)-Octahydro-5-oxo-1H-cyclopropa[g]pyrrolizine-3-carboxylic acid; 5-Oxo-hexahydro-cyclopropa[g]pyrrolizine-3-carboxylic acid; Cyclopropapyrrolizine-3-carboxylic acid derivative; Advanced Pyrrolizine Intermediate; Stereospecific Fused Bicyclic Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, GC, and NMR to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.