Description

(R)-n-((R)-1-(3,5-Bis(Trifluoromethyl)Phenyl)Ethyl)-2-(4-Fluoro-2-Methylphenyl)-n-Methyl-4-Oxo is a high-value, chiral organic intermediate with a complex, multi-ring structure featuring trifluoromethyl and fluoro substituents. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical agents, particularly those targeting the neurokinin-1 (NK1) receptor. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and fine chemical industries for developing new therapeutic candidates and manufacturing active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of Aprepitant, Fosaprepitant, and other NK1 receptor antagonists used for the prevention of chemotherapy-induced and postoperative nausea and vomiting.
• Research & Development: Serves as a critical scaffold for medicinal chemists exploring new chemical entities with potential central nervous system (CNS) activity.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing of complex, fluorinated APIs.
• Asymmetric Synthesis: Employed in studies focusing on stereoselective reactions due to its defined (R,R) configuration.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(R)-n-((R)-1-(3,5-Bis(Trifluoromethyl)Phenyl)Ethyl)-2-(4-Fluoro-2-Methylphenyl)-n-Methyl-4-Oxo
CAS No.	414910-03-5
Molecular Formula	C25H20F7NO
Molecular Weight	483.42 g/mol
Synonyms	(2R,4R)-4-[(3,5-Bis(trifluoromethyl)phenyl)methyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-2-(methylamino)-3-oxobutanamide; (R,R)-Aprepitant Intermediate; Aprepitant Key Chiral Intermediate; 2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl]-N-[(2R)-2-(4-fluoro-2-methylphenyl)-4-oxopentan-2-yl]-N-methylformamide; NK1 Receptor Antagonist Intermediate; CAS 414910-03-5
EINECS	Contact for details

Quality Control

Our (R)-n-((R)-1-(3,5-Bis(Trifluoromethyl)Phenyl)Ethyl)-2-(4-Fluoro-2-Methylphenyl)-n-Methyl-4-Oxo is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure compliance with stringent industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.