Description

Ethanone, 2-Fluoro-1-[4-(Trimethylsilyl)Phenyl]- (9Ci) is a specialized organosilicon building block featuring a unique combination of a fluorinated ketone and a trimethylsilyl-protected aromatic ring. This compound matters for its role as a critical intermediate in advanced organic synthesis, enabling the precise introduction of fluorine and silicon functionalities into target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for introducing fluorine atoms to modulate metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluoroketone moiety can enhance biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Materials: Acts as a precursor in the synthesis of functional organic materials for electronic displays, leveraging the silicon group for stability and the fluorine for electronic tuning.
• Cross-Coupling Reactions: The aryl-trimethylsilyl group can be utilized in Hiyama-type cross-coupling reactions to form biaryl structures, a common motif in many functional molecules.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and the properties of fluorinated compounds.
• Protecting Group Strategy: The trimethylsilyl group can act as a temporary protecting group for the phenol in multi-step synthetic sequences.

Basic Information

Product Name	Ethanone, 2-Fluoro-1-[4-(Trimethylsilyl)Phenyl]- (9Ci)
CAS No.	413598-85-3
Molecular Formula	C11H15FOSi
Molecular Weight	210.32 g/mol
Synonyms	2-Fluoro-1-[4-(trimethylsilyl)phenyl]ethanone; 1-[4-(Trimethylsilyl)phenyl]-2-fluoroethanone; 4'-Trimethylsilyl-2-fluoroacetophenone; 2-Fluoro-1-(4-trimethylsilylphenyl)ethan-1-one; p-(Trimethylsilyl)phenacyl fluoride; CAS 413598-85-3
EINECS	Contact for details

Quality Control

Every batch of Ethanone, 2-Fluoro-1-[4-(Trimethylsilyl)Phenyl]- (9Ci) undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment is aligned with cGMP principles for pharmaceutical intermediates. Comprehensive Certificates of Analysis (COA) detailing purity (typically by HPLC or GC), identity confirmation (by IR and NMR), and impurity profiles are available upon request for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.