Description

2-Chloro-4-(((1,1-Dimethylethyl)Dimethylsilyl)Oxy) Phenylboronic Acid is a sophisticated organoboron compound featuring a tert-butyldimethylsilyl (TBDMS) protecting group, designed for advanced synthetic chemistry. This compound matters as a key protected boronic acid building block, offering enhanced stability and selectivity in sensitive coupling reactions, particularly for pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical protected precursor in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific halogenated aryl structures.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology Probes: Utilized to create tagged or modified molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Chloro-4-(((1,1-Dimethylethyl)Dimethylsilyl)Oxy) Phenylboronic Acid
CAS No.	412343-21-6
Molecular Formula	C₁₃H₂₂BClO₂Si
Molecular Weight	284.66 g/mol
Synonyms	(2-Chloro-4-((tert-Butyldimethylsilyl)oxy)phenyl)boronic Acid; 2-Chloro-4-((tert-Butyldimethylsilyl)oxy)benzeneboronic Acid; 2-Chloro-4-(TBDMS-oxy)phenylboronic Acid; 2-Chloro-4-OTBDMS Phenylboronic Acid; 4-(tert-Butyldimethylsiloxy)-2-chlorophenylboronic Acid; Boronic acid, B-[2-chloro-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-; CAS 412343-21-6
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(((1,1-Dimethylethyl)Dimethylsilyl)Oxy) Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.